Biontech & MRNA: Revolution in der Pharmaindustrie

Der Asco Ende Mai Anfang Juni - die vollständigen abstracts werden ab 22.05 einsehbar sein:

- Bnt 327 Phase 3 erstlinie bei es-sclc - das wird interessant, aus meiner Sicht die Indikation in der bnt327 zuerst eine Zulassung erhalten wird...
- bnt142 Phase1/2 bei fortgeschrittenen claudin 6 positiven Tumoren
- bnt316 bei fortgeschrittenem melanom
- bnt316 Phase 1 Prostata Krebs (mcrpc)
- bnt324 bei Prostata Krebs (crpc)

https://meetings.asco.org/meetings/...rch?q=Biontech&pageNumber=1
 

On April 24, 2025, BioNTech SE announced that it will present data for selected assets from its diversified oncology pipeline, including mRNA cancer immunotherapies, next-generation immunomodulators, and targeted therapies, at the American Association for Cancer Research (“AACR”) Annual Meeting held in Chicago, Illinois from April 25-30, 2025. The press release is attached hereto as Exhibit 99.1.
Sowas wurde bisher selten als 6-k Dkument gemeldet. Damit müssen auch nur Sachen gemeldet werden die wesentlichen Einfluß auf das Unternehmen haben.
https://www.sec.gov/Archives/edgar/data/1776985/...urtainraiserpr.htm

 

Highlights of BioNTech’s oncology programs to be presented at AACR 2025:

•BioNTech will present preclinical data characterizing the mode of action of BNT327. BNT327 is an investigational next-generation bispecific antibody combining PD-L1 checkpoint inhibition with VEGF-A neutralization. BNT327 showed a high binding affinity to PD-L1 and VEGF-A and efficient blocking of PD-1/PD-L1 and VEGF-A/VEGFR2 signaling. Anti-tumor activity superior to single PD-1/PD-L1 blockade or anti-VEGF-A treatment was observed in multiple tumor models.

•First data for the combination of BNT327 with various ADC candidates, which are being jointly developed by BioNTech and Duality Biologics (Suzhou) Co. Ltd. (“DualityBio”), will be presented. The presentation will include preclinical evaluation of BNT327 plus ADCs, showing inhibition of tumor growth that is superior to each candidate alone. Further, early clinical data of the ongoing global Phase 1/2 trial (NCT05438329) of BNT327 in combination with BNT325/DB-1305, a TROP2-targeting ADC candidate, including safety and early efficacy data, will be presented in the poster session.

•BioNTech will present data from the Phase 1 clinical trial LuCa-MERIT-1 (NCT05142189) for its mRNA cancer immunotherapy candidate BNT116 in combination with the anti-PD1 cemiplimab in an oral presentation. The update includes safety and clinical activity data, along with biomarker data from a cohort of frail patients with advanced or metastatic non-small cell lung cancer (“NSCLC”) who were not eligible for platinum-based chemotherapy as first-line treatment. The preliminary data showed anti-tumor activity, consistent immune response induction, and a manageable safety profile.

•Preclinical data for the EpCAMx4-1BB antibody candidate BNT314/GEN1059, which is being developed in collaboration with Genmab A/S (“Genmab”), will be presented in a poster session. BNT314/GEN1059 was evaluated in combination with PD-1 inhibition in a tumor model

https://www.sec.gov/Archives/edgar/data/1776985/...bntxxaacrcurta.htm  

Es war ein rabenschwarzer Wochenausklang für die BioNTech-Aktie. Am Freitag crashte die Aktie des Mainzer Biotech-Unternehmens um -15% in den Kurskeller und verlor damit fast alle im April angefallenen Kursgewinne. Was steckte hinter dem Einbruch und sollten Anleger jetzt die Gelegenheit für einen Zukauf nutzen?
https://www.finanznachrichten.de/...er-moment-fuer-einen-kauf-486.htm