Glaube nicht das man sich wegen der QT sorgen machen muss!
Macimorelin was well tolerated in our study. The only adverse event reported frequently was dysgeusia (unpleasant taste). Nevertheless, most subjects preferred this test over the arginine+GHRH test. Only 1 subject experienced a serious adverse event of asymptomatic QT prolongation and T wave abnormality on the ECG that resolved overnight. To our knowledge, there are no prior published reports of this or other drugs in this class causing ECG abnormalities. It is worth mentioning that the individual that experienced this AE had been taking citalopram, a drug now known to cause QT prolongation (19). Other known effects of activating the ghrelin receptor including increased appetite and body weight were not seen and are unlikely to happen with a single dose.
Only 1 drug-related serious AE was reported in a control subject receiving macimorelin (2.1%), whose postdose ECG showed asymptomatic QT prolongation and nonspecific T wave abnormalities that resolved spontaneously within 24 hours. The AE was rated as serious due to the choice to hospitalize the subject as a precautionary measure. The subject had been taking citalopram, a drug that was later reported by the Food and Drug Administration (FDA) to be associated with QT prolongation (19), although the patient had stopped this medication 7 days prior to dosing (∼ 5 half-lives before the AE).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207947/
Obwohl! although the patient had stopped this medication 7 days prior to dosing (∼ 5 half-lives before the AE). [Adverse events (AEs)]
Ne, ne, citalopram ist schuld. :-) Oder?
In Foren schreiben einige, das sie noch 2 Wochen nach absetzen des Medikament mit den Nebenwirkungen zu kämpfen hatten.
Absetzreaktionen bei Beendigung einer Behandlung mit dem Arzneimittel:
.........Im Allgemeinen sind diese Symptome leicht bis mäßig schwer und gehen von selbst zurück; bei einigen Patienten können sie jedoch schwerwiegend sein und länger bestehen bleiben.
http://www.apotheken-umschau.de/Medikamente/...mtabletten-419779.html
Kann, oder auch nicht!
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