Hemispherx summarizes clinical results of Phase I/II study of Ampligen - Hemispherx Biopharma presented a summary of t
(theflyonthewall.com 02.04 14:42:46)
Hemispherx summarizes clinical results of Phase I/II study of Ampligen -
Hemispherx Biopharma presented a summary of the results of its Phase I/II
study from the poster presentation entitled "Seasonal Influenza Vaccine and a
TLR-3 Agonist, Rintatolimod --Ampligen, Given Intranasally Produced
Cross-Reactive IgA Antibodies Against Pathogenic H5N1 Influenza HA" given at
the American Society for Microbiology Biodefense Conference in Washington, DC
on January 30. When FluMist, a seasonal influenza vaccine, was administered
intranasally in conjunction with Ampligen, 92% of the subjects elaborated
specific IgA antibodies against at least one of the homologous seasonal
vaccine strains. Healthy volunteers also showed, surprisingly, enhanced IgA
levels against emerging avian influenza viruses with the potential for
causing a pandemic in humans. These antibodies were against one or more of 3
different strains of H5N1, H7N9, and H7N3. Two-thirds of these recipients
showed a greater than or equal to 4-fold increase in specific IgA levels over
baseline and some had measurable IgA levels one year after receiving FluMist
in conjunction with Ampligen. A published challenge study in adults (aged
18-45) indicates that FluMist? alone generates ≥4 fold increase in
serum HAI antibody response (a level thought to be protective) in 24% of
recipients despite the fact that 85% of recipients were estimated to have
been protected (Treanor, et al. (2000) Vaccine, 18:899). In Europe FluMist?
is approved for individuals aged 2-17 compared to ages 2-49 in the US.
S.FO HOTS.FLY HEB
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