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Title: ASSEMBLY ACTIVATING PROTEIN (AAP) AND ITS USE FOR THE MANUFACTURE OF PARVOVIRUS PARTICLES ESSENTIAL CONSISTING OF VP3
Document Type and Number: WIPO Patent Application WO/2010/099960
Kind Code: A2
Abstract: The present invention relates to nucleic acids encoding the novel parvoviral protein "assembly activating protein" (AAP), the encoded polypeptides, methods of producing the polypeptides, antibodies specific for AAP, the use of the nucleic acids for the preparation of the polypeptides, the use of the nucleic acids or the polypeptides for the preparation of the parvoviral particle and methods of producing parvoviral particles essentially consisting of VP3 by providing in addition to the coding sequence of the parvoviral structural protein VP3 a sequence fragment Z/a nucleic acid encoding AAP in the cell and expressing VP3 and fragment Z under control of a rep-independent promoter. Furthermore, the present invention relates to parvoviral particles essentially consisting of VP3 and/oror obtainable by the above method as well as expression cassettes comprising (i) a heterologous promoter and (ii) VP3 coding sequence and/oror fragment Z. The present invention further relates to a medicament, particularly a vaccine, comprising the parvoviral particles or expression cassettes and their use.
Inventors: SONNTAG, Florian (Schulzengasse 20, Heidelberg, 69120, DE)
KLEINSCHMIDT, Jürgen (Weihwiesenweg 5, Bammental, 69245, DE)
HÖRER, Markus (Josef-Beyerl-Str. 10, Planegg, 82152, DE)
LUX, Kerstin (Alfred-Schmidt-Str 37, München, 81379, DE)
Application Number: EP2010/001343
Publication Date: 09/10/2010
Filing Date: 03/04/2010
Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM (Im Neuenheimer FeId 280, Heidelberg, 69120, DE)
MEDIGENE AG (Lochhamer Straβe 11, Planegg/Martinsried, 82152, DE)
SONNTAG, Florian (Schulzengasse 20, Heidelberg, 69120, DE)
KLEINSCHMIDT, Jürgen (Weihwiesenweg 5, Bammental, 69245, DE)
HÖRER, Markus (Josef-Beyerl-Str. 10, Planegg, 82152, DE)
LUX, Kerstin (Alfred-Schmidt-Str 37, München, 81379, DE)
International Classes: C07K14/015; C12N7/04; C12N15/35; A61K39/23;
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