"11.30 Combined Molecular & Cellular Tools are Required to Assess Safety of TCR-T Immunotherapies
- There are no suitable animal models that allow TCR-T immunotherapies to be assessed for safety using in vivo models, due to HLA-restriction and species differences in the immunopeptidome of animals and man
- Molecular studies of target antigen expression in healthy tissues, spanning RNA, protein and peptide assessments are needed to judge whether healthy cells could potentially be recognized by TCR-Ts
- Functional studies analyzing both direct recognition and crossrecognition of healthy tissues are needed to establish the safety profile of TCR-Ts. Here comparisons of multiple TCRs in parallel help to select the safest TCR sequences for a given HLA-peptide specificity
Tristan Holland, Laboratory Head, TCR Discovery, Medigene" |