https://www.sec.gov/Archives/edgar/data/1553846/...0812/zk2431088.htmRedHill’s Opaganib Selected for Evaluation by BARDA
and NIH Countermeasures Programs
The U.S. government’s Chemical Medical Countermeasures (Chem MCM) Program and Chemical
Countermeasures Research Program (CCRP), managed respectively by ASPR/BARDA and
NIH/NIAID, in collaboration with Battelle1, have selected opaganib for evaluation as a potential
medical countermeasure (MCM) against Sulfur Mustard exposure
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Opaganib, a novel oral small molecule, is the first sphingosine kinase-2 (SPHK2) inhibitor
investigational drug targeting sphingolipid metabolism to be evaluated as a chemical countermeasure
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Selection for the therapeutic testing/screening program, following opaganib’s previous acceptance
into the Radiation and Nuclear Countermeasures Program (RNCP) for Acute Radiation Syndrome
(ARS), provides the potential to see broad activity across both radiation and Sulfur Mustard injuries
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Opaganib has five-year shelf-life and is easy to administer and distribute for use against potential
chemical weapon attack, if approved by the U.S. Food and Drug Administration (FDA)
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Opaganib is being developed for multiple additional indications, including COVID-19, acute