Trovagene Announces Positive Response to Treatment in Phase 1b/2 Trial of Onvansertib in Patients with KRAS-Mutated Metastatic Colorectal Cancer -- Highly aggressive KRAS-mutated tumors account for ~50% of metastatic colorectal cancer (mCRC); no targeted treatments available and response to standard-of-care is only 5% -- Decreases in tumor KRAS mutational burden in response to treatment with onvansertib in combination with FOLFIRI/Avastin® observed in all patients with a confirmed KRAS mutation -- KRAS, the trial biomarker, is a well-established measurement for the assessment of tumor mutational burden and prediction of patient response in mCRC Oct 22, 2019 |